MP-SPR Navi™

Surface Plasmon Resonance (SPR) is an established method for biomolecular interaction analysis. It is popular due to its sensitivity and its real-time label-free principle. Multi-Parametric Surface Plasmon Resonance (MP-SPR) is based on SPR theory, however its advantageous optical setup measures a full SPR curve which enables new insight into interactions.


Life Science – Lab Instrument – MP-SPR

BioNavis Ltd – Finland

Measuring principle: Multi-Parametric SPR based on a true goniometric SPR arrangement with a rotating laser
Angular range: 40 -78 degree real angular resolution 0.001˚.
Laser Set: Optional 670nm, 785nm, 850 nm and 980 nm
Liquid handling: 2 and 4 separate flow channels (depends on models). Controlled buffer flow conditions with precise syringe pumps and integrated degasser
Dynamic range: 38000 mdeg
Temperature Range in flow-cell: 15-45°C
Measurement range: ka 10^3-10^8 M^-1 Sec^-1; kd 10^-7-0.1 Sec^-1; KD = 10^3 – 10^12 M
RI range: 1.00 – 1.40
  • With PureKinetics™ feature for high quality kinetics, MP-SPR is a powerful and sensitive tool for direct measurements of small molecules.
  • MP-SPR helps you to measure biomembrane interaction kinetics as well as underlying structural changes.
  • MP-SPR is an excellent choice for drug delivery studies – from real-time targeting studies to real-time internalization with the same instrument.
  • MP-SPR enables to move from drug-target measurements, through drug-membrane interactions all the way to drug-cell interactions
  • Antibody-antigen interaction affinity and kinetic measurements can be performed in diverse liquids including complex liquids such as serum or saliva
  • MP-SPR can be combined with electrochemistry to measure catalytic interactions, electroswitching surfaces and also to develop electrochemical biosensors.
  • MP-SPR measures interactions on polymers up to 5 µm thick, which makes it the most sensitive label-free technique for biomaterial interaction studies and layer characterization
  • Antibody characterization through drug uptake routes, controlled drug release strategies, small molecule measurements, nanoparticle targeting up to drug internalization by living cell
  • MP-SPR characterization of nanoparticle interaction with a lipid bilayer and with liposomes
  • Drug delivery, with nano particle
Catalog No. Description
SPR420A-ILVES MP-SPR Navi 420A ILVES scientific instrument
SPR220A-NAALI MP-SPR Navi 220A NAALI scientific instrument
SPR210A-VASA MP-SPR Navi 210A VASA scientific instrument
SPR400-KONTIO MP-SPR Navi 400 KONTIO scientific instrument
SPR200-OTSO MP-SPR Navi 200 OTSO scientific instrument
  • Biomolecule affinity and concentration studies
  • In-situ capture of T-cells and analysis of membrane receptor affinity with biofunctionalized lipid sensor
  • Biosensor for bacteria detection from powdered milk
  • Nanoparticle uptake by cells measured using MP-SPR
  • Faster interaction measurements using MP-SPR KineticTitration
  • Analyzing dissociation kinetics of IgG from protein A using MP-SPR and PureKinetics™
  • Small molecular weight drug-protein interaction measured with MP-SPR
  • Real-time monitoring of antibody binding by parallel MP-SPR, potentiometry and impedance spectroscopy
  • Antibody and antigen interaction measured with MP-SPR